Structural Modification Medicine of the Class I Anti-cancer New Drugs
Based on the project of class I new anticancer drugs, studies on the structural modification and anti-tumor activity of derivatives containing chlorogenic acid as the skeleton were carried out to select more than 10 anti-tumor drug candidates for chlorogenic acid derivatives. Studies of some drug candidates broke through the technical bottleneck of chlorogenic acid's instability and low oral bioavailability, solved technical difficulties of oxidative degradation of chlorogenic acid in preparation, storage and manufacturing process, first achieve the purpose of oral preparations with the same effect of injection administration, which open up a new route of administration, and had good clinical application value and prospect.
Further studies have confirmed that structurally modified chlorogenic acid derivatives not only have more stable chemical properties and higher bioavailability, but also have clear target in terms of antitumor mechanism of action, which is helpful for clinical precision treatment.
Improvement of Dosage Form
The poor stability and low bioavailability of chlorogenic acid is the key technical barriers to the development and application of oral preparations. In addition to breaking though the core and key technologies of derived anti-tumor drug candidates from the structural modification of chlorogenic acid, we technically assault oral preparation of chlorogenic acid, and forms a series of oral solid preparation product development pipelines, such as tablets, granules and capsules, with solid dispersion technology as the core.
The pharmacodynamics trials in animals have preliminarily demonstrated that the oral preparation has equivalent malignant solid tumor inhibition effects with chlorogenic acid injections, and more comprehensive and systematic preclinical studies are currently ongoing.
Natural Plant Polyphenol Skin Care Factor
Jiuzhang Biotech relies on the biotechnology platform for separation and purification of oxidizable pharmaceutical natural products, refining and extracting natural plant polyphenol factor and using it as its main functional component, supplemented by a variety of natural skin-care ingredients to develop skin-care daily cosmetics with whitening, anti-wrinkle, moisturizing, antioxidant, anti-aging and other multiple effects, which can repair and remould skin, improve skin quality, make skin tender and white, and resist the invasion of dust, microorganisms or ultraviolet radiation on skin.
Natural plant polyphenol skin care factor is a strong natural antioxidant factor, which can effectively remove oxygen free radicals produced by UV light, smoke and natural metabolism in the skin to prevent DNA damage in skin cells and reduce lipid peroxidation of membrane, can also reduce melanin intermediate, reduce and decolorize melanin, so as to achieve the whitening effect.
Skin darkening, freckles, brown spots and senile plaques are all closely related to the increased activity of tyrosinase and catalase in the body. The former plays a catalytic role in the melanocyte metabolism in the skin tissue, causing increased melanin production. The latter catalyzes the decomposition of MDA by lipid peroxidation, thereby accelerating the skin aging. Therefore, to achieve real whitening effect, the activity of tyrosinase and catalase must be reduced, thereby reducing the metabolic intensity of pigment cells and the production of pigment. Natural plant polyphenol skin care factor can be used as substrate analogue of tyrosinase boundwith enzymes to reduce melanin formation. Secondly, natural plant polyphenol skin care factor also plays a whitening effect by inhibiting the expression of tyrosinase and peroxidase, or inhibiting the activity of tyrosinase to block melanogenesis.
Shrinking and tightening skin
Under the effect of enhancing permeability factor, natural plant polyphenol skin care factor compounds with proteins in skin epidermal cells by hydrophobic bond and hydrogen bond to repair collagen, which can shrink the skin, and make it more fine and tight, so as to promote the shrinking of pores, improve rough skin, make skin tighter, reduce wrinkles, and also reduce excessive sebum secretion in greasy skin.
Natural plant polyphenol skin care factor is a kind of natural product with moisturizing effect and its molecular structure contains a large number of hydrophilic phenolic hydroxyl groups that combine with water when acting on the skin and reduce water loss to achieve moisturizing effect; on the other hand, natural plant polyphenol skin care factor can reduce the decomposition of hyaluronic acid to achieve a better moisturizing effect by inhibiting the activity of enzymes. Studies of some drug candidates broke through the technical bottleneck of chlorogenic acid's instability and low oral bioavailability, solved technical difficulties of oxidative degradation of chlorogenic acid in preparation, storage and manufacturing process, first achieve the purpose of oral preparations with the same effect of injection administration, which open up a new route of administration, and had good clinical application value and prospect.
Skin aging is a complex process that includes internal processes such as senility and external factors such as radiation-induced exogenous injury because of long-term exposure to UV light. Senility and exogenous injury are mainly due to the excessive reactive oxygen species (ROS) in skin tissue resulting by oxidative stress, which degrades dermal collagen and elastic fibers and promotes skin aging. And too much reactive oxygen species (ROS) can also lead to lipid peroxidation of cell membrane, stimulate melanocytes to produce excessive melanin and result in pigmentation. Natural plant polyphenol skin care factor is a very effective natural antioxidant factor. It removes excessive reactive oxygen species (ROS) from the skin under the effect of enhancing permeability factor and acts on collagen, which accelerates the proliferation of epidermal cells and significantly inhibits the production of melanin and MDA and plays an anti-aging role.
Bacteriostatic, anti-inflammatory, anti-acne
The acne is mainly due to the sebum secreted by facial sebaceous glands does not effectively drain the skin surface, resulting in bacterial growth and localized inflammation changes. Natural plant polyphenol skin care factor has definite bacteriostatic and anti-inflammatory effect, so it can be used in the treatment of facial acne and caring.