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After years of efforts, Jiuzhang Biotech has initially established an international and domestic patent protection network for chlorogenic acid, involving crystal structure, preparation process, route of administration, dosage form design and indications, etc., and can realize comprehensive protection of the main commercial interests of chlorogenic acid-related products worldwide.

As of December 31, 2023, Jiuzhang Biotech has obtained 52 domestic patents, including 51 invention patents and 1 utility model patent, and has obtained 22 foreign patents, invention patents, including 14 patents in the United States, 4 patents in Europe, 3 patents in Japan and 1 patent in South Korea.

All patents are exclusively owned by Jiuzhang Biotech, with clear ownership, and no joint and authorized use licenses, which ensure the advantageous leading position of chlorogenic acid-related products in the market competition in the future.

Country/region

Status

Type

Number (items)

China Patents

Patent Granted

Invention   Patent

51

Utility Model

1

Foreign Patents

Patent Granted

Invention Patent

U.S.

14

Europe

4

Japan

3

Korea

1

(1) China Patents

List of Authorized Patents for Pharmacy

No.

Patent Number

Application Date

Authorization Proclamation Date

Areas

Title

Type

1

ZL201410193699.8

2014-05-09

2016-04-20

Crystal Structure

Crystalline Form of   Chlorogenic Acid and Preparation Method Thereof

Invention   Patent

2

ZL200610020939.X

2006-04-29

2009-06-17

Preparation Process

Coffee Acyl Quinic Acid Derivative   -1- Phosphate, Preparation and Application Thereof

Invention   Patent

3

ZL201310367050.9

2013-08-21

2016-09-21

Preparation Process

Pharmaceutical Composition,   Preparation Method Therefor and Use Thereof

Invention   Patent

4

ZL201410186187.9

2014-05-05

2016-08-17

Preparation Process

Method for Extracting   Chlorogenic Acid from Eucommia Leaves

Invention   Patent

5

ZL201410193742.0

2014-05-09

2017-11-07

Preparation Process

Raw Material Chlorogenic Acid   or Raw Drug Chlorogenic Acid, Method for Preparing the Same and Method for   Detecting Mass Thereof

Invention   Patent

6

ZL201410696450.9

2014-11-26

2016-01-06

Preparation Process

Method for Preparation of   Pharmaceutically Acceptable Chlorogenic Acid

Invention   Patent

7

ZL201420744944.5

2014-12-01

2015-04-15

Preparation Process

Adsorption and Separation Device   for Purifying Chlorogenic Acid

Utility   Model

8

ZL201410720632.5

2014-12-01

2016-04-20

Preparation Process

Device for Enriching and Purifying   Compound and Usage Thereof

Invention   Patent

9

ZL201510124457.8

2015-03-20

2018-03-07

Preparation Process

Chlorogenic Acid Acylate for   Improving Bioavailability of Chlorogenic Acid and Application Thereof

Invention   Patent

10

ZL201510290957.9

2015-05-29

2017-11-28

Preparation Process

Chlorogenic Acid Micro-emulsion and   Preparation Process and Application Thereof

Invention   Patent

11

ZL201510290316.3

2015-05-29

2018-03-06

Preparation Process

Chlorogenic Acid Chitosan   Microsphere and Preparation Process and Application Thereof

Invention   Patent

12

ZL201911019771.4

2019-10-24

2022-04-08

Preparation Process

Application of Chlorogenic Acid   Derivative in Drug Quality Control

Invention   Patent

13

ZL201911019770.X

2019-10-24

2022-04-26

Preparation Process

Derivative of 3- Caffeoyl Quinic   Acid and Preparation Method and Application Thereof

Invention   Patent

14

ZL201310366945.0

2013-08-21

2015-04-15

Dosage Form Design

Chlorogenic Acid   Powder-injection and Preparation Method Thereof

Invention   Patent

15

ZL201510589448.6

2015-09-15

2018-08-24

Dosage Form Design

Chlorogenic Acid Freeze-dried   Powder Injection with High Solubility and Stability

Invention   Patent

List of Authorized Patents for Disease Treatment/Beauty Surgery

No.

Patent Number

Application Date

Authorization Proclamation Date

Areas

Title

Type

1

ZL200610021897.1

2006-09-19

2011-02-02

Cancer

Application of Chlorogenic Acid in   Preparation of Medicine for Preventing and Treating Nasopharyngeal Carcinoma

Invention   Patent

2

ZL200710140602.7

2007-08-09

2009-11-11

Cancer

Application of Chlorogenic Acid in   Preparing Medicine for Treating Small Cell Lung Cancer

Invention   Patent

3

ZL201210086313.4

2012-03-28

2014-02-19

Cancer

Application of chlorogenic acid in   Cancer Control

Invention   Patent

4

ZL201410468334.1

2014-09-15

2016-05-11

Cancer

Application of Chlorogenic Acid in   Preparing Medicine for Treating Ependymoma

Invention   Patent

5

ZL201410468312.5

2014-09-15

2017-08-18

Cancer

Uses of Chlorogenic Acid in   the Preparation of Medicaments for Treatment of Oligodendroglioma

Invention   Patent

6

ZL201510079639.8

2015-02-13

2019-04-26

Cancer

Application of Chlorogenic Acid in   Preparing Medicine for Preventing and Treating Primary Cutaneous T Cell   Lymphoma

Invention   Patent

7

ZL201810559399.5

2018-06-01

2020-02-26

Cancer

Pharmaceutical Composition for   Treating Renal Cancer and Application Thereof

Invention   Patent

8

ZL201710719094.1

2017-08-21

2020-05-05

Cancer

Combined Medicine with Anti-tumor   Effect

Invention   Patent

9

ZL201710719622.3

2017-08-21

2020-06-12

Cancer

Medicine for Combined Use in   CancerTreatment

Invention   Patent

10

ZL201810206147.4

2018-03-13

2020-06-12

Cancer

Application of Pharmaceutical   Composition in Preparing Medicine for Treating Tumor Multidrug Resistance

Invention   Patent

11

ZL201810449331.1

2018-05-11

2020-06-12

Cancer

Application of Chlorogenic Acid   and Its Composition in Preparing Medicine for Treating Squamous Cell   Carcinoma

Invention   Patent

12

ZL201710672267.9

2017-08-08

2020-09-15

Cancer

Combined Anti-tumor Medicine and   Its Application in Preparing Anti-cancer Medicines

Invention   Patent

13

ZL201810374587.0

2018-04-24

2020-10-20

Cancer

Application of Chlorogenic Acid   and Its Composition in Preparing Medicine for Treating Sarcoma

Invention   Patent

14

ZL201710671362.7

2017-08-08

2020-11-06

Cancer

Combined Anti-tumor Medicine and   Its Application in Preparing Anti-cancer Medicines

Invention   Patent

15

ZL201710750731.1

2017-08-08

2021-02-26

Cancer

Combined Medicine for Treating   Diseases Related to Tumor Necrosis Factor Family

Invention   Patent

16

ZL201710671908.9

2017-08-08

2021-03-09

Cancer

Combined Anti-tumor Medicine and   Its Application in Preparing Anti-cancer Medicines

Invention   Patent

17

ZL201710672289.5

2017-08-08

2021-03-09

Cancer

Combined Anti-tumor Medicine and   Its Application in Preparing Anti-cancer Medicines

Invention   Patent

18

ZL201811401684.0

2018-11-22

2021-05-04

Tumour

Application of Chlorogenic Acid in   Preparing Medicine for Preventing or Treating Borderline Tumors

Invention   Patent

19

ZL201710752410.5

2017-08-28

2022-02-11

Tumour

Combined Medicine for Treating   Tumors

Invention   Patent

20

ZL201710750728.X

2017-08-28

2022-04-12

Tumour

Combined Medicine for Treating B   Lymphocyte-related Diseases

Invention   Patent

21

ZL201910024676.7

2019-01-10

2022-04-12

Tumour

Combined Medicine and Its   Application in Preparing Medicine for Treating High-grade Brain Tumor with   Postoperative Recurrence and Ineffective Standard Treatment

Invention   Patent

22

ZL200910246627.4

2006-07-21

2011-07-13

Blood

Application of Chlorogenic Acid in   Preparing Medicine for Treating Thrombocytopenia and Anemia

Invention   Patent

23

ZL200910246134.0

2006-07-21

2011-08-24

Blood

Application of Chlorogenic Acid in   Preparing Medicine Protecting and Repairing Spleen Hematopoietic Stem Cell   Injury

Invention   Patent

24

ZL200710128491.8

2007-07-26

2010-01-27

Blood

Application of Chlorogenic Acid in   Preparing Medicine for Medicine or Food for Resisting Anoxia

Invention   Patent

25

ZL200680024175.X

2006-07-21

2010-08-25

Cell Growth and Differentiation

Application of Chlorogenic Acid in   Preparing Medicine with Effect of Increasing Bone Marrow Cells

Invention   Patent

26

ZL200910246630.6

2006-07-21

2011-09-07

Bones and Muscles

Application of Chlorogenic Acid in   Preparing Medicine for Treating Bone Marrow Fibrosis

Invention   Patent

27

ZL201510063970.0

2015-02-06

2017-03-07

Bones and Muscles

Application of Chlorogenic Acid in   Preparing Medicine for Treating Bone Marrow Fibrosis

Invention   Patent

28

ZL201510579797.X

2015-09-14

2018-05-18

Nerve

Compound Preparation for Treating   Depression

Invention   Patent

29

ZL201810814892.7

2018-07-24

2019-10-08

Nerve

Drug Combination for   Treatment of Amyotrophic Lateral Sclerosis, Preparation Method and Use   Thereof

Invention   Patent

30

ZL201110386854.4

2011-11-28

2013-07-10

Other Diseases

Liver-protecting Medicine or   Health-care Product Composition and Preparation Method and Application   Thereof

Invention   Patent

31

ZL201310210438.8

2011-11-28

2014-11-05

Other Diseases

Liver-protecting Medicine or   Health-care Product Composition and Preparation Method and Application   Thereof

Invention   Patent

32

ZL202110509462.6

2021-05-11

2022-08-05

Other Diseases

Pharmaceutical Composition for   Treating Hyperlipidemia and Preparation Method Thereof

Invention   Patent

33

ZL202110956753.X

2021-08-19

2022-12--16

Other Diseases

Composition with Skin Repairing   Effect

Invention   Patent

34

ZL202110109946.1

2021-01-27

2023-06-02

Other Diseases

Application of Pharmaceutical   Composition Containing Chlorogenic Acid in Preparing Medicine for Treating   Pathological Jaundice

Invention   Patent

35

ZL201611130322.3

2016-12-09

2023-06-20

Other Diseases

Application of Chlorogenic Acid in   Preparing Appetite-stimulating Medicine or Health Product

Invention   Patent

36

ZL202210115388.4

2022-02-07

2023-10-13

Other Diseases

Application of Chlorogenic Acid   Composition in Preparing Medicine for Preventing or Treating Pain

Invention   Patent

37

ZL202110108965.2

2021-06-11

2022/3/22

Cosmetic Medicine

Application of Injection   Composition Containing Chlorogenic Acid in Preparing Injection with Skin   Whitening Effect

Invention   Patent


(2) Foreign Patents

List of Foreign Patents

NO.

Patent Number

PCT Application Date

Areas

Title

U.S

1

9,918,956

2013-08-21

Dosage   Form Design

Chlorogenic Acid   Powder-injection and Preparation Method Thereof

2

10,238,702

2013-08-21

Preparation Process

Pharmaceutical Composition,   Preparation Method Therefor and Use Thereof

3

10,246,401

2014-05-16

Preparation Process

Crystalline Form of   Chlorogenic Acid and Preparation Method Thereof

4

10,004,713

2014-10-14

Tumour

Uses of Chlorogenic Acid in   the Preparation of Medicaments for Treatment of Oligodendroglioma

5

9,884,036

2014-09-23

Immune

Uses of Chlorogenic Acid in   the Preparation of Medicaments for Treatment of Psoriasis

6

10,314,806

2015-11-18

Preparation Process

Preparation Containing Chlorogenic   Acid Crystal Form and Use Thereof

7

10,189,769

2014-11-26

Preparation Process

Method for Preparation of   Pharmaceutically Acceptable Chlorogenic Acid

8

10,058,525

2016-01-26

Immune

Application of Chlorogenic   Acid in Preparing Medicines for Treating Lupus Erythematosus

9

10,265,289

2016-02-02

Tumour

Method and Medicines for   Treating Melanoma

10

11,135,160

2017-02-20

Cancer

Use of Chlorogenic Acid in   Preparing Pharmaceuticals for Treatment of LAG-3-Mediated Disease

11

11,376,267

2019-06-28

Rare Diseases

Drug Combination for   Treatment of Amyotrophic Lateral Sclerosis, Preparation Method and Use   Thereof

12

11,547,715

2018-12-27

Tumour

Use of Chlorogenic Acid in   Preparation of Drug for Treating Chordoma

13

11,596,598

2020-10-01

Dosage   Form Design

Chlorogenic Acid-Containing   Composition for Nasal Administration

14

11,628,199

2018-08-17

Cancer

Medicine for Combined Use in   Cancer Treatment

Europe

1

3225615

2014-11-26

Preparation Process

Method for Preparation of   Pharmaceutically Acceptable Chlorogenic Acid

2

3199151

2014-09-23

Immune

Uses of Chlorogenic Acid in   the Preparation of Medicaments for Treatment of Psoriasis

3

3141540

2014-05-16

Preparation Process

Crystalline Form of   Chlorogenic Acid and Preparation Method Thereof

4

3909576

2020-01-10

Other Diseases

Use of Chlorogenic Acid in   Preparing Medicine or Pharmaceutical Composition for Preventing or Treating   Pain

Japan

1

6473803

2014-05-05

Preparation Process

Method for Extracting Chlorogenic Acid from   Eucommia Leaves

2

6379286

2014-05-09

Preparation Process

Raw Material Chlorogenic Acid or Raw Drug Chlorogenic Acid,   Method for Preparing the Same and Method for Detecting Mass Thereof

3

6488379

2014-11-26

Preparation Process

Method for Preparation of Pharmaceutically   Acceptable Chlorogenic Acid

Korea

1

10-1893964

2014-05-16

Preparation Process

Crystalline Form of   Chlorogenic Acid and Preparation Method Thereof