Glioblastoma (GBM) is recognized as a "terminal disease" among brain tumors. The reasons for its dreadfulness are multifaceted. Despite the concurrent use of the "three major treatments"—surgery, radiotherapy, and chemotherapy—the median survival time for patients remains a mere 15 months. This tumor can be likened to an unending "battle of attack and defense." Even when the visible tumor is seemingly "eradicated," residual cells may lie dormant, awaiting an opportunity to re-emerge and trigger recurrence.

IntroductionTwentyyearsafterthecompletionoftheHumanGenomeProject,ithasbeenfoundthatwearelikechildrenwhopossessadictionarybutdonotunderstandgrammar.Confrontedwiththe"humanbodyuniverse"composedof3.7tril...

 Hastheterm"fasting"notbeendiscussedforsometime?ThelastdiscussionoffastingandcancertreatmentbyQidianGao(aself-designatedname,likelyreferringtoapersonorentityrelatedtothecontent)occurrednearlytwoy...

The field of brain tumor treatment is confronted with a perplexing puzzle: Why does immunotherapy, which has repeatedly achieved remarkable results in other cancers, frequently fail in the treatment of malignant gliomas? A study titled "Programs, origins and immunomodulatory functions of myeloid cells in glioma," published in Nature on February 26th, provides a revolutionary answer. A group of "double agents" has been discovered in the microenvironment of gliomas: myeloid cells, which constitute half of the tumor, carry four distinct genetic programs and repeatedly switch their identities between promoting cancer and combating cancer. These cells may either release inflammatory factors to awaken the immune system or phagocytose anti-cancer signals through scavenger receptors, and they can even transform commonly used hormonal drugs into "accomplices" of immunosuppression.

This paper explores chlorogenic acid's role in curbing cellular senescence and preventing photoaging in mouse skin, identifying enolase 1 (ENO1) as its protein target.

The liver, a vital organ in the human body, is responsible for numerous critical functions. Nutrient metabolism, energy storage, and blood sugar regulation are among these functions. Additionally, the liver plays a pivotal role in detoxification and the elimination of harmful substances and drugs.